Hepatocyte-based flow analytical bioreactor for online xenobiotics metabolism bioprediction
نویسندگان
چکیده
منابع مشابه
Modular bioreactor for primary human hepatocyte culture: Medium flow stimulates expression and activity of detoxification genes
Down-regulation of detoxification genes, notably cytochrome P450 (CYPs), in primary hepatocyte cultures is a long-standing and major concern. We evaluated the influence of medium flow in this model. Hepatocytes isolated from 12 different liver donors were cultured either in a multichamber modular bioreactor (MCmB, flow rate 250-500 μL/min) or under standard/static conditions, and the expression...
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ژورنال
عنوان ژورنال: Nanobiomedicine
سال: 2017
ISSN: 1849-5435,1849-5435
DOI: 10.1177/1849543517702898